Peer-reviewed journal articles
- Mochi Liu, Anuj K. Sharma, Joshua W. Shaevitz, Andrew M. Leifer. "Temporal processing and context dependency in C. elegans response to mechanosensation" in press at eLife Preprint available on arXiv arXiv:1803.04085, 12 Mar 2018. [ PDF ]
- Jeffrey P. Nguyen, Ashley N. Linder, George S. Plummer, Joshua W. Shaevitz, Andrew M. Leifer. "Automatically tracking neurons in a moving and deforming brain" PLOS Computational Biology 13(5): e1005517 (2017). [PDF, Movie, Data and Code]
- Jeffrey P. Nguyen, Frederick B. Shipley, Ashley N. Linder, George S. Plummer, Mochi Liu, Sagar U. Setru, Joshua W. Shaevitz, Andrew M. Leifer. "Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans" Proceedings of the National Academy of Sciences of the United States of America, 10.1073/pnas.1507110112, Published online before print December 28, (2015). [PDF and Movies S1, S2, S3 and S4; Code, Processed and Raw Data]. Commentary.
- Frederick B. Shipley, Christopher M. Clark, Mark J. Alkema, Andrew M. Leifer. "Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans." Frontiers in Neural Circuits 8:28. (2014). [PDF and Video]
- Steven J. Husson, Alexander Gottschalk, Andrew M. Leifer. "Optogenetic manipulation of neural activity in C. elegans: from synapse to circuits and behavior." Biology of the Cell (2013). [PDF via arXiv]
- Jamie L. Donnelly, Christpoher M. Clark, Andrew M. Leifer, Marian Haburacak, Jennifer K. Pirri, Michael M. Francis, Aravinthan D. T. Samuel, and Mark J. Alkema. “Monoaminergic orchestration of motorprograms in a complex behavior in C. elegans.” PLoS Biology 11(4): e1001529 (2013). [PDF] & Synopsis.
- Quan Wen, Michelle D. Po, Elizabeth Hulme, Sway Chen, Xinyu Liu, Sen Wai Kwok, Marc Gershow, Andrew M. Leifer, Victoria Butler, Christopher Fang-Yen, Taizo Kawano, William R. Schafer, George Whitesides, Mattieu Wyart, Dmitri Chklovskii and Aravinthan Samueal, "Proprioceptive coupling within motor neurons drives C. elegans forward locomotion." Neuron, 76, 750-761 (2012). [PDF]
- Chenxiang Lin, Ralf Jungmann, Andrew M. Leifer, Chao Li, Daniel Levner, George M. Church, William M. Shih, Peng Yin. "Sub-micrometer geometrically encoded fluorescent barcodes self-assembled from DNA." Nature Chemistry, 4, 832–839 (2012).
- Andrew M. Leifer, Christopher Fang-Yen, Marc Gershow, Mark Alkema, Aravinthan D.T. Samuel, "Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans," Nature Methods, 8, 147–152 (2011). [PDF]
- Kevin J. Coakley, David S. Simons, Andrew M. Leifer. "Secondary Ion Mass Spectrometry Measurements of Isotopic Ratios: Correction for Time Varying Count Rate." International Journal of Mass Spectrometry, 204 (2005) 107-120.
Popular press articles featuring our work
- Emily Singer, "Capturing the Whole Brain in Action," Simons Foundation, 22 December 2016.
- Emily Reynolds, "Neural activity of worm captured in mesmerising display," Wired, 5 January 2016.
- Steve Dent, "Watch a worm’s brain light up as it plots its next move," Engadget, 31 December 2015.
- Esther Inglis-Arkell, "We can now watch the inside of a worm brain at work, Gizmodo, 30 December 2015.
- Morgan Kelly, "3-D footage of nematode brains links neurons with motion and behavior," News at Princeton, 30 December 2015.
- "First videos created of whole brain neural activity in an unrestrained Animal," MIT Technology Review, January 25 2015.
- Laura Sanders, "Making a worm do more than squirm," Science News 16 January 2011.
- David Castelvecchi, "Single Worm Neurons Remotely Controlled with Lasers", Scientific American 16 January 2011.
Video Recorded Lectures
- Andrew Leifer, "How does a nervous system transition between behavior states?", Princeton Neuroscience Institute Seminar, Princeton University, 16 February 2016. 29 minutes.
- Andrew Leifer, "Whole-brain neural dynamics and behavior in freely moving C. elegans", Emerging Tools for Acquisition and Interpretation of Whole-Brain Functional Data, HHMI Janelia Research Campus, 3 November 2015. 12 minutes.
- Andrew Leifer, "Whole-brain neural dynamics and behavior in freely moving nematodes", Stanford Neurosciences Institute Seminar Series, Stanford University, 17 February 2015. 1 hour 2 minutes.
Lecture slides
- Andrew Leifer, "Optical neurophysiology in freely behaving C. elegans" C. elegans topic meeting: neuronal development, synaptic function and behavior , University of Wisconsin Madison, 9 July 2014. [PDF] [Bibliography]